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Article

Evolution of HLA class II molecules: Allelic and amino acid site variability across populations.

Genetics - 1 May 1999

Salamon H, Klitz W, Easteal S, Gao X, Erlich H A, Fernandez-Viña M, Trachtenberg E A, McWeeney S K, Nelson M P, Thomson G

Abstract excerpt

Analysis of the highly polymorphic beta1 domains of the HLA class II molecules encoded by the DRB1, DQB1, and DPB1 loci reveals contrasting levels of diversity at the allele and amino acid site levels. Statistics of allele frequency distributions, based on Watterson's homozygosity statistic F, reveal distinct evolutionary patterns for these loci in ethnically diverse samples (26 populations for DQB1 and DRB1 and...

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Source

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Identifiers

PMID: 10224269
DOI: 10.1093/genetics/152.1.393
PMCID: PMC1460587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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