Red Queen Processes Drive Positive Selection on Major Histocompatibility Complex (MHC) Genes.

doi:10.1371/journal.pcbi.1004627

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Article

Red Queen Processes Drive Positive Selection on Major Histocompatibility Complex (MHC) Genes.

PLoS computational biology - 1 Nov 2015

Ejsmond Maciej Jan, Radwan Jacek

Abstract excerpt

Major Histocompatibility Complex (MHC) genes code for proteins involved in the incitation of the adaptive immune response in vertebrates, which is achieved through binding oligopeptides (antigens) of pathogenic origin. Across vertebrate species, substitutions of amino acids at sites responsible for the specificity of antigen binding (ABS) are positively selected. This is attributed to pathogen-driven balancing...

Topics

Alleles
Computational Biology
Computer Simulation
Evolution, Molecular
Humans
Major Histocompatibility Complex
Models, Genetic
Mutation
Selection, Genetic

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Identifiers

PMID: 26599213
DOI: 10.1371/journal.pcbi.1004627
PMCID: PMC4658181

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