Article
Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin.
The Journal of biological chemistry - 10 Jun 2005
Litjens Sandy H M, Wilhelmsen Kevin, de Pereda José M, Perrakis Anastassis, Sonnenberg Arnoud
Abstract excerpt
The binding of plectin to the beta4 subunit of the alpha6beta4 integrin is a critical step in the formation of hemidesmosomes. An important interaction between these two proteins occurs between the actin-binding domain (ABD) of plectin and the first pair of fibronectin type III (FNIII) domains and a small part of the connecting segment of beta4. Previously, a few amino acids, critical for this interaction, were...
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