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Article

Flexibility in the N-terminal actin-binding domain: clues from in silico mutations and molecular dynamics.

Proteins - 1 Apr 2015

Chakravarty Devlina, Chakraborti Soumyananda, Chakrabarti Pinak

Abstract excerpt

Dystrophin is a long, rod-shaped cytoskeleton protein implicated in muscular dystrophy (MDys). Utrophin is the closest autosomal homolog of dystrophin. Both proteins have N-terminal actin-binding domain (N-ABD), a central rod domain and C-terminal region. N-ABD, composed of two calponin homology (CH) subdomains joined by a helical linker, harbors a few disease causing missense mutations. Although the two proteins...

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Identifiers

PMID: 25620004
DOI: 10.1002/prot.24767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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