Article
Flexibility in the N-terminal actin-binding domain: clues from in silico mutations and molecular dynamics.
Proteins - 1 Apr 2015
Chakravarty Devlina, Chakraborti Soumyananda, Chakrabarti Pinak
Abstract excerpt
Dystrophin is a long, rod-shaped cytoskeleton protein implicated in muscular dystrophy (MDys). Utrophin is the closest autosomal homolog of dystrophin. Both proteins have N-terminal actin-binding domain (N-ABD), a central rod domain and C-terminal region. N-ABD, composed of two calponin homology (CH) subdomains joined by a helical linker, harbors a few disease causing missense mutations. Although the two proteins...
Topics
- Actins
- Amino Acid Sequence
- Animals
- Binding Sites
- Dystrophin
- Humans
- Membrane Glycoproteins
- Microfilament Proteins
- Molecular Dynamics Simulation
- Molecular Sequence Data
- Muscular Dystrophies