Article
A secondary structure model of the integrin alpha subunit N-terminal domain based on analysis of multiple alignments.
Cell adhesion and communication - 1 Oct 1994
Tuckwell D S, Humphries M J, Brass A
Abstract excerpt
The integrins are alpha/beta heterodimeric proteins which mediate cell-matrix and cell-cell interactions. Current data indicate that the N-terminal moiety of the alpha subunit is involved in ligand binding. This region of the receptor is made up of a seven-fold repeated sequence of unknown structure which contains EF-hand-like putative divalent cation-binding sites. Recent studies have shown that multiple...
Topics
- Amino Acid Sequence
- Animals
- Consensus Sequence
- Cricetinae
- Drosophila
- Genetic Variation
- Humans
- Integrins
- Macromolecular Substances
- Mice
- Models, Molecular
- Molecular Sequence Data