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Article

Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin.

The Journal of biological chemistry - 8 Mar 2002

Chang David D, Hoang Bao Q, Liu Jenny, Springer Timothy A

Abstract excerpt

Icap1 alpha is a 200-amino acid protein that binds to the COOH-terminal 13 amino acids ((786)AVTTVVNPKYEGK(798)) of the integrin beta(1) subunit. Alanine scanning mutagenesis of this region revealed that Val(787), Val(790), and (792)NPKY(795) are critical for Icap1 alpha binding. The NPXY motif is a known binding substrate for phosphotyrosine binding (PTB) domain proteins. The sequences of Icap1 alpha, residues...

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PMID: 11741908
DOI: 10.1074/jbc.M109031200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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