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Article

Dynamic Regulation of α-Actinin's Calponin Homology Domains on F-Actin.

Biophysical journal - 29 Mar 2016

Shams Hengameh, Golji Javad, Garakani Kiavash, Mofrad Mohammad R K

Abstract excerpt

α-Actinin is an essential actin cross-linker involved in cytoskeletal organization and dynamics. The molecular conformation of α-actinin's actin-binding domain (ABD) regulates its association with actin and thus mutations in this domain can lead to severe pathogenic conditions. A point mutation at lysine 255 in human α-actinin-4 to glutamate increases the binding affinity resulting in stiffer cytoskeletal...

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Identifiers

PMID: 27028653
DOI: 10.1016/j.bpj.2016.02.024
PMCID: PMC4816760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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