Article
The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2004
Boyartchuk Victor, Rojas Mauricio, Yan Bo-Shiun, Jobe Ousman, Hurt Nicholas, Dorfman David M, Higgins Darren E, Dietrich William F, Kramnik Igor
Abstract excerpt
Epidemiological, clinical, and experimental approaches have convincingly demonstrated that host resistance to infection with intracellular pathogens is significantly influenced by genetic polymorphisms. Using a mouse model of infection with virulent Mycobacterium tuberculosis (MTB), we have previously identified the sst1 locus as a genetic determinant of host resistance to tuberculosis. In this study we...
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