Progression of Pulmonary Tuberculosis and Efficiency of Bacillus Calmette-Guerin Vaccination Are Genetically Controlled via a Common sst1 -Mediated Mechanism of Innate Immunity

Abstract excerpt

Using a mouse model for genetic analysis of host resistance to virulent Mycobacterium tuberculosis, we have identified a genetic locus sst1 on mouse chromosome 1, which controls progression of pulmonary tuberculosis. In vitro, this locus had an effect on macrophage-mediated control of two intracellular bacterial pathogens, M. tuberculosis and Listeria monocytogenes. In this report, we investigated a specific...

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