Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine

1 Feb 2020

Abstract excerpt

Abstract The Tec kinase IL-2–inducible T cell kinase (ITK) regulates the expression of TCR-induced genes. Itk−/− T cell responses are impaired but not absent. ITK inhibition prevented colitis disease progression and impaired T cell migration to the colon in mice. To examine the function of ITK in T cell migration to the intestine, we examined the number of gut T cells in Itk−/− mice and then evaluated their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32034085
DOI: 10.4049/immunohorizons.1900093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the IntestinePMID 32034085Read ↗

The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.Semantic proximity Read ↗

A Unique Subset of Self-specific Intraintestinal T Cells Maintains Gut IntegritySemantic proximity Read ↗

Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.Semantic proximity Read ↗

Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract.Semantic proximity Read ↗

Targeted Deletion of Integrin-Linked Kinase Reveals a Role in T-Cell Chemotaxis and SurvivalSemantic proximity Read ↗

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4Semantic proximity Read ↗

Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, and iNKT-cell cytokine production.Semantic proximity Read ↗

Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function.Semantic proximity Read ↗

Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment.Semantic proximity Read ↗

Itk is not essential for CD28 signaling in naive T cells.Semantic proximity Read ↗

Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal MucosaSemantic proximity Read ↗

Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.