Article
Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation.
Immunity - 1 Oct 1995
Cai Y C, Cefai D, Schneider H, Raab M, Nabavi N, Rudd C E
Abstract excerpt
CD28 costimulatory signals are required for lymphokine production and T cell proliferation. CD28 signaling recruits the intracellular proteins PI 3-kinase, ITK, and GRB-2/SOS. PI 3-kinase and GRB-2/SOS bind the CD28 cytoplasmic pYMNM motif via SH2 domains. We generated CD28 pYMNM mutants and foun...
Topics
- Animals
- Antigens, CD
- B7-2 Antigen
- CD28 Antigens
- CHO Cells
- Cricetinae
- Humans
- Interleukin-2
- Lymphocyte Activation
- Membrane Glycoproteins
- Mice
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Signal Transduction
- T-Lymphocytes