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Article

Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Aug 2006

Hekmat-Scafe Daria S, Lundy Miriam Y, Ranga Rakhee, Tanouye Mark A

Abstract excerpt

During a critical period in the developing mammalian brain, there is a major switch in the nature of GABAergic transmission from depolarizing and excitatory, the pattern of the neonatal brain, to hyperpolarizing and inhibitory, the pattern of the mature brain. This switch is believed to play a major role in determining neuronal connectivity via activity-dependent mechanisms. The GABAergic developmental switch may...

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Identifiers

PMID: 16943550
DOI: 10.1523/JNEUROSCI.4998-05.2006
PMCID: PMC6675325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila.PMID 16943550Read ↗

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Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizuresSemantic proximity Read ↗

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A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.Semantic proximity Read ↗

Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant.Semantic proximity Read ↗

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<i>Nckx30c</i> , a <i>Drosophila</i> K <sup>+</sup> -dependent Na <sup>+</sup> /Ca <sup>2+</sup> exchanger, regulates temperature-sensitive convulsions and age-related neurodegenerationSemantic proximity Read ↗

NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.Semantic proximity Read ↗

The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans.Semantic proximity Read ↗

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