Article
Characterizing Binding Interactions That Are Essential for Selective Transport through the Nuclear Pore Complex.
International journal of molecular sciences - 8 Oct 2021
Lennon Kathleen M, Soheilypour Mohammad, Peyro Mohaddeseh, Wakefield Devin L, Choo Grace E, Mofrad Mohammad R K, Jovanovic-Talisman Tijana
Abstract excerpt
Specific macromolecules are rapidly transported across the nuclear envelope via the nuclear pore complex (NPC). The selective transport process is facilitated when nuclear transport receptors (NTRs) weakly and transiently bind to intrinsically disordered constituents of the NPC, FG Nups. These two types of proteins help maintain the selective NPC barrier. To interrogate their binding interactions in vitro, we...
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