Article

Mechanosensitivity of nucleocytoplasmic transport

2021-07-24

Abstract excerpt

Mechanical force controls fundamental cellular processes in health and disease, and increasing evidence shows that the nucleus both experiences and senses applied forces. Here we show that nuclear forces differentially control passive and facilitated nucleocytoplasmic transport, setting the rules for the mechanosensitivity of shuttling proteins. We demonstrate that nuclear force increases permeability across nucle...

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Identifiers and source

Literature Corpus work: b237096d-dc50-58fc-8837-31b562eb6d05
DOI: 10.1101/2021.07.23.453478

Open publication

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