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Article

Autonomy and robustness of translocation through the nuclear pore complex: a single-molecule study.

The Journal of cell biology - 6 Oct 2008

Dange Thomas, Grünwald David, Grünwald Antje, Peters Reiner, Kubitscheck Ulrich

Abstract excerpt

All molecular traffic between nucleus and cytoplasm occurs via the nuclear pore complex (NPC) within the nuclear envelope. In this study we analyzed the interactions of the nuclear transport receptors kapalpha2, kapbeta1, kapbeta1DeltaN44, and kapbeta2, and the model transport substrate, BSA-NLS, with NPCs to determine binding sites and kinetics using single-molecule microscopy in living cells. Recombinant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18824568
DOI: 10.1083/jcb.200806173
PMCID: PMC2557044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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