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Regulation of azole drug susceptibility by Candida albicans protein kinase CK2

7 Mar 2005

Abstract excerpt

Fluconazole resistance of the fungal pathogen Candida albicans can arise through several mechanisms, but the responsible genes and pathways are poorly understood. We report here that mutations in CKA2, identified through an insertional mutagenesis screen, confer fluconazole resistance. CKA2 and its homologue CKA1 specify catalytic subunits of protein kinase CK2. Although cka1 mutations have little effect on...

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PMID: 15813744
DOI: 10.1111/j.1365-2958.2005.04562.x

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