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Article

[Effect of MDR1 polymorphic expression on oral disposition of cyclosporine A].

Yao xue xue bao = Acta pharmaceutica Sinica - 1 Dec 2004

Jiao Zheng, Liang Hui-qi, Ding Jun-jie, Li Zhong-dong, Shi Xiao-jin, Zhong Ming-kang

Abstract excerpt

AIM: To determine the relationship between C3435T mutation in exon 26 of the human multidrug resistant 1 gene and cyclosporine (CsA) pharmacokinetic (PK) parameters among healthy Chinese volunteers by nonlinear mixed effect model (NONMEM). METHODS: Twenty healthy subjects were given orally a single dose of 500 mg CsA in microemulsion solution. Blood CsA concentrations were measured with HPLC and the genotype for...

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PMID: 15813023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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