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Article

MDR1 C3435T polymorphisms correlate with cyclosporine levels in de novo renal recipients.

Transplantation proceedings - 1 Nov 2006

Foote C J, Greer W, Kiberd B A, Fraser A, Lawen J, Nashan B, Belitsky P

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene correlate with the intestinal function of P-glycoprotein (PGP). PGP serves as a hydrophobic export pump that extrudes cyclosporine (CsA) across the luminal membrane thus preventing CsA absorption. These genetic variants may predict CsA exposure levels in the early posttransplantation period. METHODS: CsA absorption profiles...

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Source

Identifiers

PMID: 17112845
DOI: 10.1016/j.transproceed.2006.08.120

Genes

PGP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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