Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of MDR1 C1236T polymorphism on cyclosporine pharmacokinetics: A systematic review and meta-analysis.

Medicine - 1 Nov 2017

Chen Zhe, Zhang Lingli, Yang Chunsong, Jiang Zhimei, Shen Hongxin, Gui Ge

Abstract excerpt

BACKGROUND: Cyclosporine (CsA) is one of the immunosuppressive drugs, whose pharmacokinetic characteristics vary greatly among individuals. The published data reveal conflicting effects of the polymorphism of MDR1 exon 12 SNP C1236T on the pharmacokinetics of cyclosporine.This study aims to conduct a meta-analysis to investigate the effect of SNP C1236T on the pharmacokinetics of cyclosporine. METHODS: A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to China

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclosporine

Share to Dose-Response Relationship, Drug

Share to Immunosuppressive Agents

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Transplantation

Source

Open in PubMed Open full text

Identifiers

PMID: 29381954
DOI: 10.1097/MD.0000000000008700
PMCID: PMC5708953

Genes

VIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of MDR1 C1236T polymorphism on cyclosporine pharmacokinetics: A systematic review and meta-analysis.PMID 29381954Read ↗

Association of CYP3A4*1B genotype with Cyclosporin A pharmacokinetics in renal transplant recipients: A meta-analysis.Semantic proximity Read ↗

Impact of CYP3A4 and MDR1 gene (G2677T) polymorphisms on dose requirement of the cyclosporine in renal transplant Egyptian recipients.Semantic proximity Read ↗

Meta-analysis of the effect of MDR1 C3435T polymorphism on cyclosporine pharmacokinetics.Semantic proximity Read ↗

Association of MDR1, CYP3A4*18B, and CYP3A5*3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients.Semantic proximity Read ↗

The effect of CYP3A5 polymorphism on dose-adjusted cyclosporine concentration in renal transplant recipients: a meta-analysis.Semantic proximity Read ↗

Population pharmacokinetic study of cyclosporine in Chinese renal transplant recipients.Semantic proximity Read ↗

The Effect of ABCB1 C3435T Polymorphism on Cyclosporine Dose Requirements in Kidney Transplant Recipients: A Meta-Analysis.Semantic proximity Read ↗

Association of polymorphism of CYP3A4, ABCB1, ABCC2, ABCG2, NFKB1, POR, and PXR with the concentration of cyclosporin A in allogeneic haematopoietic stem cell transplantation recipients.Semantic proximity Read ↗

Effects of genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 on cyclosporine pharmacokinetics after renal transplantation.Semantic proximity Read ↗

[Effect of MDR1 polymorphic expression on oral disposition of cyclosporine A].Semantic proximity Read ↗

Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients.Semantic proximity Read ↗

Functional G1199A ABCB1 polymorphism may have an effect on cyclosporine blood concentration in renal transplanted patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.