Transfer-messenger RNA unfolds as it transits the ribosome.

doi:10.1261/rna.7269305

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Article

Transfer-messenger RNA unfolds as it transits the ribosome.

RNA (New York, N.Y.) - 1 May 2005

Wower Iwona K, Zwieb Christian, Wower Jacek

Abstract excerpt

In bacteria, translation of mRNAs lacking stop codons produces truncated polypeptides and traps ribosomes in unproductive complexes. Potentially harmful truncated proteins are tagged with short peptides encoded by the mRNA-like domain of tmRNA and targeted for digestion by housekeeping proteases. We show that altered Escherichia coli transfer-messenger RNAs (tmRNAs) produce in vivo fusion proteins with peptide...

Topics

Base Sequence
Codon, Terminator
Escherichia coli
Mutation
Nucleic Acid Conformation
Peptide Chain Termination, Translational
Protein Biosynthesis
RNA, Bacterial
Ribosomes

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Identifiers

PMID: 15811920
DOI: 10.1261/rna.7269305
PMCID: PMC1370753

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