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Article

Pre-binding of small protein B to a stalled ribosome triggers trans-translation.

The Journal of biological chemistry - 18 Jun 2004

Hallier Marc, Ivanova Natalia, Rametti Armelle, Pavlov Michael, Ehrenberg Måns, Felden Brice

Abstract excerpt

To rescue stalled ribosomes, eubacteria employ a molecule, transfer messenger RNA (tmRNA), which functions both as a tRNA and as an mRNA. With the help of small protein B (SmpB), tmRNA restarts protein synthesis and adds by the trans-translation mechanism a peptide tag to the stalled protein to t...

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Source

Identifiers

PMID: 15069072
DOI: 10.1074/jbc.M314086200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15069072-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Pre-binding of small protein B to a stalled ribosome triggers trans-translation.PMID 15069072Read ↗

Small protein B interacts with the large and the small subunits of a stalled ribosome during trans-translation.Semantic proximity Read ↗

A previously uncharacterized role for small protein B (SmpB) in transfer messenger RNA-mediated trans-translation.Semantic proximity Read ↗

Ribosomal protein S1 influences trans-translation in vitro and in vivo.Semantic proximity Read ↗

SmpB contributes to reading frame selection in the translation of transfer-messenger RNA.Semantic proximity Read ↗

Transfer-messenger RNA unfolds as it transits the ribosome.Semantic proximity Read ↗

The many faces of ribosome translocation along the mRNA: reading frame maintenance, ribosome frameshifting and translational bypassingSemantic proximity Read ↗

Requirements for resuming translation in chimeric transfer-messenger RNAs of Escherichia coli and Mycobacterium tuberculosis.Semantic proximity Read ↗

Bifunctional transfer-messenger RNA.Semantic proximity Read ↗

rRNA mutations that inhibit transfer-messenger RNA activity on stalled ribosomes.Semantic proximity Read ↗

Trans-translation in Helicobacter pylori: essentiality of ribosome rescue and requirement of protein tagging for stress resistance and competence.Semantic proximity Read ↗

SmpB functions in various steps of trans-translation.Semantic proximity Read ↗

Function of the SmpB tail in transfer-messenger RNA translation revealed by a nucleus-encoded form.Semantic proximity Read ↗

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