Article
Ribosomal protein S1 influences trans-translation in vitro and in vivo.
Nucleic acids research - 1 Jan 2007
Saguy Matthieu, Gillet Reynald, Skorski Patricia, Hermann-Le Denmat Sylvie, Felden Brice
Abstract excerpt
When the bacterial ribosome stalls on a truncated mRNA, transfer-messenger RNA (tmRNA) acts initially as a transfer RNA (tRNA) and then as a messenger RNA (mRNA) to rescue the ribosome and add a peptide tag to the nascent polypeptide that targets it for degradation. Ribosomal protein S1 binds tmRNA but its functional role in this process has remained elusive. In this report, we demonstrate that, in vitro, S1 is...
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