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Article

Requirements for resuming translation in chimeric transfer-messenger RNAs of Escherichia coli and Mycobacterium tuberculosis.

BMC molecular biology - 15 Sept 2014

Wower Iwona K, Zwieb Christian, Wower Jacek

Abstract excerpt

BACKGROUND: Trans-translation is catalyzed by ribonucleprotein complexes composed of SmpB protein and transfer-messenger RNA. They release stalled ribosomes from truncated mRNAs and tag defective proteins for proteolytic degradation. Comparative sequence analysis of bacterial tmRNAs provides considerable insights into their secondary structures in which a tRNA-like domain and an mRNA-like region are connected by...

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Identifiers

PMID: 25220282
DOI: 10.1186/1471-2199-15-19
PMCID: PMC4236655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirements for resuming translation in chimeric transfer-messenger RNAs of Escherichia coli and Mycobacterium tuberculosis.PMID 25220282Read ↗

Transfer-messenger RNA unfolds as it transits the ribosome.Semantic proximity Read ↗

Escherichia coli tmRNA lacking pseudoknot 1 tags truncated proteins in vivo and in vitro.Semantic proximity Read ↗

SmpB contributes to reading frame selection in the translation of transfer-messenger RNA.Semantic proximity Read ↗

A functional interaction of SmpB with tmRNA for determination of the resuming point of trans-translation.Semantic proximity Read ↗

Bifunctional transfer-messenger RNA.Semantic proximity Read ↗

Importance of the conserved nucleotides around the tRNA-like structure of Escherichia coli transfer-messenger RNA for protein tagging.Semantic proximity Read ↗

Pre-binding of small protein B to a stalled ribosome triggers trans-translation.Semantic proximity Read ↗

tmRNA determinants required for facilitating nonstop mRNA decay.Semantic proximity Read ↗

Determinants on tmRNA for initiating efficient and precise trans-translation: some mutations upstream of the tag-encoding sequence of Escherichia coli tmRNA shift the initiation point of trans-translation in vitro.Semantic proximity Read ↗

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