Article
tmRNA determinants required for facilitating nonstop mRNA decay.
RNA (New York, N.Y.) - 1 Dec 2006
Mehta Preeti, Richards Jamie, Karzai A Wali
Abstract excerpt
In bacteria, ribosomes stalled on nonstop mRNAs are rescued by tmRNA in a unique process called trans-translation. The two known tmRNA functions in trans-translation are (1) a tRNA-like function, which transfers the partially synthesized protein fragment to itself; and (2) an mRNA-like function, which enables ribosomes to resume and terminate translation on tmRNA as a surrogate template. We present evidence to...
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