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Article

A functional interaction of SmpB with tmRNA for determination of the resuming point of trans-translation.

RNA (New York, N.Y.) - 1 Oct 2007

Konno Takayuki, Kurita Daisuke, Takada Kazuma, Muto Akira, Himeno Hyouta

Abstract excerpt

In trans-translation, transfer-messenger RNA (tmRNA), possessing a dual function as a tRNA and an mRNA, relieves a stalled translation on the ribosome with the help of SmpB. Here, we established an in vitro system using Escherichia coli translation and trans-translation factors to evaluate two steps of trans-translation, peptidyl transfer from peptidyl-tRNA to alanyl-tmRNA and translation of the resume codon on...

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Identifiers

PMID: 17698641
DOI: 10.1261/rna.604907
PMCID: PMC1986810

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A functional interaction of SmpB with tmRNA for determination of the resuming point of trans-translation.PMID 17698641Read ↗

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Requirements for resuming translation in chimeric transfer-messenger RNAs of Escherichia coli and Mycobacterium tuberculosis.Semantic proximity Read ↗

tmRNA determinants required for facilitating nonstop mRNA decay.Semantic proximity Read ↗

Transfer-messenger RNA unfolds as it transits the ribosome.Semantic proximity Read ↗

Importance of the conserved nucleotides around the tRNA-like structure of Escherichia coli transfer-messenger RNA for protein tagging.Semantic proximity Read ↗

Functional and structural analysis of a pseudoknot upstream of the tag-encoded sequence in E. coli tmRNA.Semantic proximity Read ↗

Pre-binding of small protein B to a stalled ribosome triggers trans-translation.Semantic proximity Read ↗

Interaction of SmpB with ribosome from directed hydroxyl radical probing.Semantic proximity Read ↗

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