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Article

rRNA mutations that inhibit transfer-messenger RNA activity on stalled ribosomes.

Journal of bacteriology - 1 Jan 2010

Crandall Jacob, Rodriguez-Lopez Milagros, Pfeiffer Michael, Mortensen Bailey, Buskirk Allen

Abstract excerpt

In eubacteria, stalled ribosomes are rescued by a conserved quality-control mechanism involving transfer-messenger RNA (tmRNA) and its protein partner, SmpB. Mimicking a tRNA, tmRNA enters stalled ribosomes, adds Ala to the nascent polypeptide, and serves as a template to encode a short peptide that tags the nascent protein for destruction. To further characterize the tagging process, we developed two genetic...

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Identifiers

PMID: 19897649
DOI: 10.1128/JB.01178-09
PMCID: PMC2805313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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