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Article

The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells.

Molecular and cellular biology - 1 Oct 2001

Nag A, Bondar T, Shiv S, Raychaudhuri P

Abstract excerpt

The damaged-DNA binding protein DDB consists of two subunits, DDB1 (127 kDa) and DDB2 (48 kDa). Mutations in the DDB2 subunit have been detected in patients suffering from the repair deficiency disease xeroderma pigmentosum (group E). In addition, recent studies suggested a role for DDB2 in global genomic repair. DDB2 also exhibits transcriptional activity. We showed that expression of DDB1 and DDB2 stimulated...

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Source

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Identifiers

PMID: 11564859
DOI: 10.1128/MCB.21.20.6738-6747.2001
PMCID: PMC99852

Genes

DDB2
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells.PMID 11564859Read ↗

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.Semantic proximity Read ↗

Tumor-prone phenotype of the DDB2-deficient mice.Semantic proximity Read ↗

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stabilitySemantic proximity Read ↗

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.Semantic proximity Read ↗

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.Semantic proximity Read ↗

Emerging Roles of DDB2 in CancerSemantic proximity Read ↗

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Abnormal regulation of DDB2 gene expression in xeroderma pigmentosum group E strains.Semantic proximity Read ↗

Xeroderma pigmentosum group E and DDB2, a smaller subunit of damage-specific DNA binding protein: proposed classification of xeroderma pigmentosum, Cockayne syndrome, and ultraviolet-sensitive syndrome.Semantic proximity Read ↗

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