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Article

p53 Binds and Activates the Xeroderma Pigmentosum <i>DDB2</i> Gene in Humans but Not Mice

1 May 2002

Abstract excerpt

The DDB2 gene, which is mutated in xeroderma pigmentosum group E, enhances global genomic repair of cyclobutane pyrimidine dimers and suppresses UV-induced mutagenesis. Because DDB2 transcription increases after DNA damage in a p53-dependent manner, we searched for and found a region in the human DDB2 gene that binds and responds transcriptionally to p53. The corresponding region in the mouse DDB2 gene shared...

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Identifiers

PMID: 11971958
DOI: 10.1128/mcb.22.10.3247-3254.2002

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