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Article

Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma.

Virchows Archiv : an international journal of pathology - 1 Sept 2014

Alves Mariana Rezende, Carneiro Felipe Cavalcanti, Lavorato-Rocha André Mourão, da Costa Walter Henriques, da Cunha Isabela Werneck, de Cássio Zequi Stênio, Guimaraes Gustavo Cardoso, Soares Fernando Augusto, Carraro Dirce Maria, Rocha Rafael Malagoli

Abstract excerpt

The most common subtype of renal cell carcinoma is the clear cell type (ccRCC), accounting for 75 % of cases. Inactivation of VHL gene is thought to be an early event in ccRCC carcinogenesis. Our intention was to assess whether VHL mutational status might provide useful predictive or prognostic information in patients with ccRCC. VHL messenger RNA (mRNA) expression was analyzed by in situ hybridization and its...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 25027579
DOI: 10.1007/s00428-014-1629-z

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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