Article
Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination.
Oncogene - 2 Feb 2012
Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine G N, Kracht M, Schmitz M L, Burstein E
Abstract excerpt
The nuclear factor (NF)-κB transcription factor has essential roles in inflammation and oncogenesis. Its ubiquitous RelA subunit is regulated by several post-translational modifications, including phosphorylation, ubiquitination and acetylation. Ubiquitination promotes the termination of RelA-dependent transcription, but its regulation is incompletely understood. Through mass spectrometry analysis of...
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