Article
In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Apr 2014
Yu Tao, Calvo Laura, Anta Begoña, López-Benito Saray, López-Bellido Roger, Vicente-García Cristina, Tessarollo Lino, Rodriguez Raquel E, Arévalo Juan C
Abstract excerpt
Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling, trafficking, and degradation of the receptors. However, the in vivo consequences of Trk ubiquitination remain to be addressed. We have developed a mouse model with a mutation in the TrkA neurotrophin receptor (P782S) that results in reduced ubiquitination due to a lack of binding to the E3 ubiquitin ligase, Nedd4-2. In...
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