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Article

Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes.

The Journal of biological chemistry - 17 Jul 2009

Hislop James N, Henry Anastasia G, Marchese Adriano, von Zastrow Mark

Abstract excerpt

Ubiquitination is essential for the endocytic sorting of various G protein-coupled receptors to lysosomes. Here we identify a distinct function of this covalent modification in controlling the later proteolytic processing of receptors. Mutation of all cytoplasmic lysine residues in the murine delta-opioid receptor blocked receptor ubiquitination without preventing ligand-induced endocytosis of receptors or their...

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Identifiers

PMID: 19433584
DOI: 10.1074/jbc.M109.001644
PMCID: PMC2740561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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