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Article

Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.

Journal of molecular biology - 22 Apr 2005

Kumar Abhinav, Mandiyan Valsan, Suzuki Yoshihisa, Zhang Chao, Rice Julie, Tsai James, Artis Dean R, Ibrahim Prabha, Bremer Ryan

Abstract excerpt

Pim1, a serine/threonine kinase, is involved in several biological functions including cell survival, proliferation, and differentiation. While pim1 has been shown to be involved in several hematopoietic cancers, it was also recently identified as a target of aberrant somatic hypermutation in diffuse large cell lymphoma (DLCL), the most common form of non-Hodgkin's lymphoma. The crystal structures of Pim1 in apo...

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Share to Apoproteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 15808862
DOI: 10.1016/j.jmb.2005.02.039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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