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Article

Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure.

PloS one - 1 Jan 2013

Lori Clorinda, Lantella Antonella, Pasquo Alessandra, Alexander Leila T, Knapp Stefan, Chiaraluce Roberta, Consalvi Valerio

Abstract excerpt

Pim-1 kinase, a serine/threonine protein kinase encoded by the pim proto-oncogene, is involved in several signalling pathways such as the regulation of cell cycle progression and apoptosis. Many cancer types show high expression levels of Pim kinases and particularly Pim-1 has been linked to the initiation and progression of the malignant phenotype. In several cancer tissues somatic Pim-1 mutants have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23755147
DOI: 10.1371/journal.pone.0064824
PMCID: PMC3673989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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