PIM1 kinase as a target for cancer therapy

doi:10.1517/13543784.2012.668527

Article

PIM1 kinase as a target for cancer therapy

4 Mar 2012

Abstract excerpt

INTRODUCTION: Inhibition of protein kinases has become a standard of modern clinical oncology. PIM1 belongs to a novel class of serine/threonine kinases with distinct molecular and biochemical features regulating various oncogenic pathways, for example hypoxia response, cell cycle progression and apoptosis resistance. PIM1 is overexpressed in human cancer diseases and has been associated with metastasis and...

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