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Article

Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.

Oncotarget - 27 Sept 2016

Peters Tara L, Li Lingxiao, Tula-Sanchez Ana A, Pongtornpipat Praechompoo, Schatz Jonathan H

Abstract excerpt

The PIM family kinases promote growth and survival of tumor cells and are expressed in a wide variety of human cancers. Their potential as therapeutic targets, however, is complicated by overlapping activities with multiple other pathways and remains poorly defined in most clinical scenarios. Here we explore activity of the new pan-PIM inhibitor PIM447 in a variety of lymphoid-derived tumors. We find strong...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Gene Expression Regulation, Neoplastic

Share to Lymphoma, Large B-Cell, Diffuse

Share to Protein Biosynthesis

Share to Protein Kinase Inhibitors

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 27556513
DOI: 10.18632/oncotarget.11457
PMCID: PMC5325370

Genes

PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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