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Fighting Tumor Cell Survival: Advances in the Design and Evaluation of Pim Inhibitors

13 Nov 2010

Abstract excerpt

The Pim (provirus insertion site of Moloney murine leukemia virus) family of serine/threonine protein kinases possesses the fundamental characteristics critical for the biology of eukaryotes, in particular, survival and malignant transformation of cells. The members of this protein family (Pim-1 to Pim-3) are aberrantly expressed in human tumors, most frequently in prostate cancer and hematological malignancies....

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PMID: 20939820
DOI: 10.2174/092986710793348554

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