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Using Insights into Pim1 Structure to Design New Anticancer Drugs

1 Dec 2010

Abstract excerpt

Human Pim1 (proviral integration site for Moloney murine leukemia virus) kinase is a 313-amino acid serine-threonine kinase that possesses several biological functions in cell survival, proliferation and differentiation, and its overexpression has been observed in a number of human cancers. Indeed, this kinase is a proto-oncogene that has been implicated in early transformation and tumor progression, especially...

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PMID: 21158732
DOI: 10.2174/138161210794454996

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