Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study.

doi:10.1194/jlr.M400382-JLR200

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Article

Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study.

Journal of lipid research - 1 Jul 2005

Yang Qiong, Lai Chao-Qiang, Parnell Laurence, Cupples L Adrienne, Adiconis Xian, Zhu Yueping, Wilson Peter W F, Housman David E, Shearman Amanda M, D'Agostino Ralph B, Ordovas Jose M

Abstract excerpt

High density lipoprotein cholesterol (HDL-C) is inversely associated with coronary heart disease and has a genetic component; however, linkage to HDL-C is not conclusive. Subfractions of HDL, such as HDL(3)-C, may be better phenotypes for linkage studies. Using HDL(3)-C levels measured on 907 Framingham Heart Study subjects from 330 families around 1987, we conducted a genome-wide variance components linkage...

Topics

Adult
Chromosome Mapping
Chromosomes, Human, Pair 6
Cohort Studies
DNA Probes
Female
Genetic Linkage
Genome, Human
Humans
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoproteins, HDL

Lipoproteins, HDL3

Male

Massachusetts

Microsatellite Repeats

Middle Aged

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Source

Open in PubMed

Identifiers

PMID: 15805549
DOI: 10.1194/jlr.M400382-JLR200

Genes

PLAGL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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