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Article

Genetics of HDL-C: a causal link to atherosclerosis?

Current atherosclerosis reports - 1 Jun 2013

van Capelleveen Julian C, Bochem Andrea E, Motazacker M Mahdi, Hovingh G Kees, Kastelein John J P

Abstract excerpt

Prospective epidemiological studies have consistently reported an inverse association between HDL cholesterol (HDL-C) levels and the risk of cardiovascular disease (CVD). However, large intervention trials on HDL-C-increasing drugs and recent Mendelian randomization studies have questioned a causal relationship between HDL-C and atherosclerosis. HDL-C levels have been shown to be highly heritable, and the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23591671
DOI: 10.1007/s11883-013-0326-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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