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A genome search identifies major quantitative trait loci on human chromosomes 3 and 4 that influence cholesterol concentrations in small LDL particles.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 1999

Rainwater D L, Almasy L, Blangero J, Cole S A, VandeBerg J L, MacCluer J W, Hixson J E

Abstract excerpt

Small, dense LDL particles are associated with increased risk of cardiovascular disease. To identify the genes that influence LDL size variation, we performed a genome-wide screen for cholesterol concentrations in 4 LDL size fractions. Samples from 470 members of randomly ascertained families were typed for 331 microsatellite markers spaced at approximately 15 cM intervals. Plasma LDLs were resolved by using...

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PMID: 10073986
DOI: 10.1161/01.atv.19.3.777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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