Article
Linkage and association analyses identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families.
Human genetics - 1 Jun 2010
Wijsman Ellen M, Rothstein Joseph H, Igo Robert P, Brunzell John D, Motulsky Arno G, Jarvik Gail P
Abstract excerpt
Familial combined hyperlipidemia (FCHL) is a complex trait leading to cardiovascular disease (CVD) risk. Elevated levels and size of apolipoprotein B (apoB) and low-density lipoprotein (LDL) are associated with FCHL, which is genetically heterogeneous and is likely caused by rare variants. We carried out a linkage-based genome scan of four large FCHL pedigrees for apoB level that is independent of LDL: apoB level...
Topics
- Apolipoproteins B
- Cardiovascular Diseases
- Cholesterol, LDL
- Chromosomes, Human, Pair 4
- Genetic Association Studies
- Genetic Heterogeneity
- Genetic Linkage
- Humans
- Hyperlipidemia, Familial Combined
- Lipoproteins, LDL
- Particle Size
- Pedigree
- Phenotype
- Polymorphism, Single Nucleotide