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Article

Linkage and association analyses identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families.

Human genetics - 1 Jun 2010

Wijsman Ellen M, Rothstein Joseph H, Igo Robert P, Brunzell John D, Motulsky Arno G, Jarvik Gail P

Abstract excerpt

Familial combined hyperlipidemia (FCHL) is a complex trait leading to cardiovascular disease (CVD) risk. Elevated levels and size of apolipoprotein B (apoB) and low-density lipoprotein (LDL) are associated with FCHL, which is genetically heterogeneous and is likely caused by rare variants. We carried out a linkage-based genome scan of four large FCHL pedigrees for apoB level that is independent of LDL: apoB level...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20383777
DOI: 10.1007/s00439-010-0819-2
PMCID: PMC2877194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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