Article
Genetic causes of high and low serum HDL-cholesterol.
Journal of lipid research - 1 Aug 2010
Weissglas-Volkov Daphna, Pajukanta Päivi
Abstract excerpt
Plasma levels of HDL cholesterol (HDL-C) have a strong inherited basis with heritability estimates of 40-60%. The well-established inverse relationship between plasma HDL-C levels and the risk of coronary artery disease (CAD) has led to an extensive search for genetic factors influencing HDL-C concentrations. Over the past 30 years, candidate gene, genome-wide linkage, and most recently genome-wide association...
Topics
- Animals
- Cholesterol, HDL
- Genetic Diseases, Inborn
- Genome-Wide Association Study
- Heredity
- Humans
- Life Style
- Multifactorial Inheritance
- Phenotype