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Article

Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease.

European journal of human genetics : EJHG - 1 May 2010

Kangas-Kontio Tiia, Kakko Sakari, Tamminen Minna, von Rohr Peter, Hoeschele Ina, Juvonen Tatu, Kere Juha, Savolainen Markku J

Abstract excerpt

Coronary heart disease (CHD) is the leading cause of mortality in Western societies. Its risk is inversely correlated with plasma high-density lipoprotein cholesterol (HDL-C) levels, and approximately 50% of the variability in these levels is genetically determined. In this study, the aim was to carry out a whole-genome scan for the loci regulating plasma HDL-C levels in 35 well-defined Finnish extended pedigrees...

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PMID: 19935834
DOI: 10.1038/ejhg.2009.202
PMCID: PMC2987327

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