Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.

doi:10.1128/MCB.26.1.343-353.2006

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.

Molecular and cellular biology - 1 Jan 2006

Miyabe Izumi, Morishita Takashi, Hishida Takashi, Yonei Shuji, Shinagawa Hideo

Abstract excerpt

The Schizosaccharomyces pombe rad60 gene is essential for cell growth and is involved in repairing DNA double-strand breaks. Rad60 physically interacts with and is functionally related to the structural maintenance of chromosomes 5 and 6 (SMC5/6) protein complex. In this study, we investigated the role of Rad60 in the recovery from the arrest of DNA replication induced by hydroxyurea (HU). rad60-1 mutant cells...

Topics

Antineoplastic Agents
Cell Cycle
Cell Cycle Proteins
Checkpoint Kinase 2
Chromosomal Proteins, Non-Histone
Chromosome Segregation
Chromosomes, Fungal
DNA Helicases
DNA Repair
DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA, Fungal

Drug Resistance, Neoplasm

Gene Deletion

Hydroxyurea

Mitosis

Mutation

Nucleic Acid Conformation

Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 16354704
DOI: 10.1128/MCB.26.1.343-353.2006
PMCID: PMC1317627

Genes

SMC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.PMID 16354704Read ↗

A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.Semantic proximity Read ↗

Schizosaccharomyces pombe Cds1Chk2 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60.Semantic proximity Read ↗

Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.Semantic proximity Read ↗

Novel pof1 mutation suppresses the sensitivity to DNA replication inhibitor in fission yeast RecQ helicase mutant.Semantic proximity Read ↗

Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer.Semantic proximity Read ↗

Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.Semantic proximity Read ↗

Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

Brc1-dependent recovery from replication stress.Semantic proximity Read ↗

Fission yeast genes involved in coupling mitosis to completion of DNA replication.Semantic proximity Read ↗

A recombination repair gene of Schizosaccharomyces pombe, rhp57, is a functional homolog of the Saccharomyces cerevisiae RAD57 gene and is phylogenetically related to the human XRCC3 gene.Semantic proximity Read ↗

Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.