Article
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.
The American journal of pathology - 1 May 2000
Kuismanen S A, Holmberg M T, Salovaara R, de la Chapelle A, Peltomäki P
Abstract excerpt
Microsatellite instability (MSI) is a hallmark of hereditary nonpolyposis colorectal cancer, and in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 and MLH1. MSI also occurs in 15% of sporadic colorectal cancers, but in these tumors, its basis is less well characterized. We investigated 46 sporadic MSI+ colorectal cancers for changes in MSH2 and MLH1 protein expression,...
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