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Article

Clinical applications of NOD2/CARD15 mutations in Crohn's disease.

Acta gastroenterologica Latinoamericana - 1 Mar 2007

Barreiro-de Acosta Manuel, Peña Amado S

Abstract excerpt

The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step in the immunopathogenesis of inflammatory bowel disease. The gene explains about 20% of the genetic susceptibility CARD15 mutations are present in 30-50% of CD patients compared to 7-20% of healthy controls. The three risk alleles R702W, G908R and 1007fsInsC in NOD2 associated with...

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Identifiers

PMID: 17486745

Genes

NOD2
TNF

Provenance

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