Article
CARD15/NOD2 mutations in Crohn's disease.
Annals of the New York Academy of Sciences - 1 Aug 2006
Hugot Jean-Pierre
Abstract excerpt
Inflammatory bowel diseases (IBDs) are complex genetic disorders characterized by a complex interplay between genetic and environmental risk factors. At least ten genes or anonymous loci have been proposed to play a role in IBD. Among them, the best studied is CARD15/NOD2, a gene coding for a protein involved in bacterial recognition by cells involved in innate immunity. Despite a large amount of work, a...
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