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Article

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients.

Digestive diseases (Basel, Switzerland) - 1 Jan 2003

Török Helga-Paula, Glas Jürgen, Lohse Peter, Folwaczny Christian

Abstract excerpt

The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immunopathogenesis of inflammatory bowel disease. CARD15 functions as an intracellular receptor for bacterial components and thus represents an important link between inflammatory bowel disease and innate immunity. Three major CARD15/NOD2 gene mutations have...

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Identifiers

PMID: 14752224
DOI: 10.1159/000075357

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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