Article
Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model.
Cancer genetics and cytogenetics - 15 Apr 2005
Roshani L, Mallon P, Sjostrand E, Wedekind D, Szpirer J, Szpirer C, Hedrich H J, Klinga-Levan K
Abstract excerpt
Most cancers are genetically complex and heterogeneous, a serious obstacle to identifying specific genes underlying the disease. If inbred animal models are used, then both the genetic constitution and environmental influences can be carefully controlled. Females of the BDII inbred rat strain are genetically predisposed to endometrial cancer; more than 90% of virgin BDII females will develop endometrial...
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